| December 1, 1965 | vs Nebraska Cornhuskers | L 88-101 |
| December 4, 1965 | vs Notre Dame Fighting Irish | W 97-79 |
| December 11, 1965 | vs Houston Cougars | L 57-82 |
| December 14, 1965 | vs Illinois Fighting Illini | L 70-90 |
| December 17, 1965 | vs Washington Huskies | L 67-81 |
| December 18, 1965 | vs West Virginia Mountaineers | L 93-101 |
| December 20, 1965 | vs Montana | W 76-72 |
| December 22, 1965 | vs Cincinnati Bearcats | L 74-87 |
| December 29, 1965 | vs Pennsylvania | W 84-70 |
| January 3, 1966 | vs Marquette Golden Eagles | W 73-72 |
| January 8, 1966 | vs Iowa Hawkeyes | W 69-68 |
| January 11, 1966 | vs Illinois Fighting Illini | L 64-80 |
| January 27, 1966 | vs Hardin-Simmons | W 83-63 |
| January 29, 1966 | vs Michigan Wolverines | L 67-69 |
| January 31, 1966 | vs Ohio State Buckeyes | L 81-87 |
| February 5, 1966 | vs Michigan State Spartans | L 65-79 |
| February 7, 1966 | vs Indiana Hoosiers | W 79-78 |
| February 12, 1966 | vs Michigan Wolverines | L 102-120 |
| February 19, 1966 | vs Michigan State Spartans | W 78-77 |
| February 21, 1966 | vs Northwestern Wildcats | L 65-76 |
| February 26, 1966 | vs Iowa Hawkeyes | L 70-80 |
| February 28, 1966 | vs Northwestern Wildcats | W 90-62 |
| March 5, 1966 | vs Purdue Boilermakers | W 69-68 |
| March 7, 1966 | vs Minnesota Golden Gophers | W 87-74 |
