| December 1, 1965 | vs Davidson Wildcats | W 87-86 |
| December 4, 1965 | vs Maryland Terrapins | L 66-87 |
| December 6, 1965 | vs Virginia Cavaliers | L 94-97 |
| December 13, 1965 | vs Vanderbilt Commodores | L 82-102 |
| December 17, 1965 | vs Duquesne | W 94-80 |
| December 28, 1965 | vs Ohio State Buckeyes | L 81-88 |
| December 30, 1965 | vs Cincinnati Bearcats | L 87-117 |
| January 1, 1966 | vs Duke Blue Devils | L 76-92 |
| January 5, 1966 | vs North Carolina Tar Heels | L 83-99 |
| January 8, 1966 | vs Georgia Tech Yellow Jackets | W 96-80 |
| January 10, 1966 | vs Virginia Cavaliers | W 99-87 |
| January 12, 1966 | vs Saint Joseph's | L 72-97 |
| January 15, 1966 | vs Duke Blue Devils | L 81-101 |
| January 29, 1966 | vs Davidson Wildcats | W 82-80 |
| February 1, 1966 | vs Clemson Tigers | L 71-72 |
| February 3, 1966 | vs North Carolina Tar Heels | L 87-115 |
| February 5, 1966 | vs South Carolina Gamecocks | W 93-62 |
| February 7, 1966 | vs Maryland Terrapins | L 78-86 |
| February 10, 1966 | vs Virginia Tech Hokies | L 85-110 |
| February 12, 1966 | vs South Carolina Gamecocks | W 65-63 |
| February 14, 1966 | vs Clemson Tigers | L 89-104 |
| February 19, 1966 | vs Virginia Tech Hokies | L 84-90 |
| February 22, 1966 | vs Duke Blue Devils | W 99-98 |
| February 26, 1966 | vs North Carolina State Wolfpack | L 75-101 |
| February 28, 1966 | vs North Carolina State Wolfpack | L 100-121 |
| March 3, 1966 | vs Duke Blue Devils | L 73-103 |
