| November 25, 2020 | vs Towson | W 89-54 |
| November 25, 2020 | vs Maine | |
| November 25, 2020 | vs Saint Peter's | |
| November 27, 2020 | vs Florida Gators | |
| November 27, 2020 | vs San Francisco | L 60-61 |
| December 1, 2020 | vs Saint Francis (PA) | W 76-51 |
| December 4, 2020 | vs Kent State | W 71-64 |
| December 9, 2020 | vs Michigan State Spartans | |
| December 12, 2020 | vs William & Mary | |
| December 13, 2020 | vs William & Mary | |
| December 16, 2020 | vs Wake Forest Demon Deacons | |
| December 19, 2020 | vs Villanova Wildcats | |
| December 22, 2020 | vs William & Mary | W 76-40 |
| December 26, 2020 | vs Gonzaga Bulldogs | L 75-98 |
| December 30, 2020 | vs Notre Dame Fighting Irish | W 66-57 |
| January 2, 2021 | vs Virginia Tech Hokies | |
| January 6, 2021 | vs Wake Forest Demon Deacons | W 70-61 |
| January 9, 2021 | vs Boston College Eagles | W 61-49 |
| January 13, 2021 | vs Notre Dame Fighting Irish | W 80-68 |
| January 16, 2021 | vs Clemson Tigers | W 85-50 |
| January 20, 2021 | vs North Carolina State Wolfpack | |
| January 23, 2021 | vs Georgia Tech Yellow Jackets | W 64-62 |
| January 25, 2021 | vs Syracuse Orange | W 81-58 |
| January 30, 2021 | vs Virginia Tech Hokies | L 51-65 |
| February 3, 2021 | vs North Carolina State Wolfpack | W 64-57 |
| February 6, 2021 | vs Louisville Cardinals | |
| February 6, 2021 | vs Pittsburgh Panthers | W 73-66 |
| February 10, 2021 | vs Georgia Tech Yellow Jackets | W 57-49 |
| February 13, 2021 | vs North Carolina Tar Heels (9) | W 60-48 |
| February 15, 2021 | vs Florida State Seminoles | L 60-81 |
| February 20, 2021 | vs Duke Blue Devils | L 65-66 |
| February 24, 2021 | vs Pittsburgh Panthers | |
| February 24, 2021 | vs North Carolina State Wolfpack | L 61-68 |
| March 1, 2021 | vs Miami (FL) Hurricanes | W 62-51 |
| March 6, 2021 | vs Louisville Cardinals | W 68-58 |
| March 11, 2021 | vs Syracuse Orange | W 72-69 |
| March 20, 2021 | vs Ohio | L 58-62 |
