| November 12, 2010 | vs Alcorn State | W 88-56 |
| November 15, 2010 | vs Texas A&M-Corpus Christi | W 86-65 |
| November 25, 2010 | vs Boston College Eagles | L 65-67 |
| November 26, 2010 | vs Manhattan | W 74-45 |
| November 28, 2010 | vs Temple | W 54-51 |
| December 2, 2010 | vs Stephen F. Austin | W 62-53 |
| December 4, 2010 | vs Pacific | W 79-59 |
| December 8, 2010 | vs Prairie View | W 87-63 |
| December 11, 2010 | vs Washington Huskies (21) | W 63-62 |
| December 18, 2010 | vs Arkansas Razorbacks | W 71-62 |
| December 21, 2010 | vs Wagner | W 86-51 |
| December 31, 2010 | vs McNeese State | W 66-57 |
| January 3, 2011 | vs Nicholls State | W 66-55 |
| January 8, 2011 | vs Oklahoma Sooners | W 69-51 |
| January 12, 2011 | vs Oklahoma State Cowboys | W 71-48 |
| January 15, 2011 | vs Missouri Tigers | W 91-89 |
| January 19, 2011 | vs Texas Longhorns | L 60-81 |
| January 22, 2011 | vs Kansas State Wildcats | W 64-56 |
| January 29, 2011 | vs Nebraska Cornhuskers | L 48-57 |
| January 31, 2011 | vs Texas Longhorns | L 49-69 |
| February 5, 2011 | vs Baylor Bears | L 74-76 |
| February 9, 2011 | vs Colorado Buffaloes | W 73-70 |
| February 12, 2011 | vs Texas Tech Red Raiders | W 70-67 |
| February 16, 2011 | vs Iowa State Cyclones | W 71-66 |
| February 19, 2011 | vs Oklahoma State Cowboys | W 67-66 |
| February 23, 2011 | vs Oklahoma Sooners | W 61-47 |
| February 26, 2011 | vs Baylor Bears | L 51-58 |
| March 2, 2011 | vs Kansas Jayhawks | L 51-64 |
| March 5, 2011 | vs Texas Tech Red Raiders | W 66-54 |
| March 10, 2011 | vs Missouri Tigers | W 86-71 |
| March 11, 2011 | vs Texas Longhorns | L 58-70 |
| March 18, 2011 | vs Florida State Seminoles | L 50-57 |
