| November 28, 1980 | vs Western Kentucky | L 69-73 |
| November 29, 1980 | vs Iona Gaels | L 69-79 |
| December 1, 1980 | vs Marshall | L 85-116 |
| December 6, 1980 | vs Clemson Tigers | L 69-82 |
| December 19, 1980 | vs Citadel | W 83-81 |
| December 20, 1980 | vs Furman | W 62-53 |
| December 23, 1980 | vs Texas Longhorns | W 74-70 |
| December 30, 1980 | vs Florida State Seminoles | W 80-78 |
| January 3, 1981 | vs East Tennessee State | W 72-68 |
| January 5, 1981 | vs Cleveland State | L 76-82 |
| January 10, 1981 | vs Rhode Island Rams | L 84-94 |
| January 15, 1981 | vs Manhattan | W 90-62 |
| January 17, 1981 | vs Marquette Golden Eagles | W 91-89 |
| January 21, 1981 | vs Temple | L 64-68 |
| January 24, 1981 | vs Davidson Wildcats | W 103-88 |
| January 26, 1981 | vs Richmond | W 93-77 |
| January 28, 1981 | vs Hofstra | W 90-72 |
| January 31, 1981 | vs Notre Dame Fighting Irish | L 84-94 |
| February 4, 1981 | vs Penn State Nittany Lions | W 70-60 |
| February 8, 1981 | vs Clemson Tigers | L 91-115 |
| February 11, 1981 | vs Furman | W 87-74 |
| February 14, 1981 | vs William & Mary | L 68-77 |
| February 18, 1981 | vs Florida State Seminoles | W 83-70 |
| February 21, 1981 | vs Boston University | W 93-86 |
| February 23, 1981 | vs Georgia Southern | W 106-69 |
