| December 2, 1965 | vs Virginia Tech Hokies | L 88-94 |
| December 4, 1965 | vs Detroit Mercy | W 82-75 |
| December 11, 1965 | vs Butler Bulldogs | W 84-77 |
| December 13, 1965 | vs Ohio | L 73-74 |
| December 27, 1965 | vs St. John's (NY) | W 77-75 |
| December 29, 1965 | vs UCLA Bruins | L 70-82 |
| December 30, 1965 | vs Vanderbilt Commodores | L 72-94 |
| January 4, 1966 | vs Notre Dame Fighting Irish | W 109-92 |
| January 8, 1966 | vs Northwestern Wildcats | L 97-111 |
| January 10, 1966 | vs Michigan State Spartans | L 78-89 |
| January 15, 1966 | vs Illinois Fighting Illini | W 93-87 |
| January 24, 1966 | vs Michigan State Spartans | L 74-92 |
| January 29, 1966 | vs Minnesota Golden Gophers | L 75-91 |
| February 5, 1966 | vs Minnesota Golden Gophers | L 61-66 |
| February 7, 1966 | vs Iowa Hawkeyes (9) | W 66-58 |
| February 12, 1966 | vs Ohio State Buckeyes (1) | L 54-68 |
| February 19, 1966 | vs Michigan Wolverines | L 94-128 |
| February 21, 1966 | vs Indiana Hoosiers | W 77-68 |
| February 26, 1966 | vs Michigan Wolverines | L 85-105 |
| February 28, 1966 | vs Illinois Fighting Illini | L 81-98 |
| March 5, 1966 | vs Wisconsin Badgers | L 68-69 |
| March 7, 1966 | vs Ohio State Buckeyes | W 92-86 |
