| December 5, 1959 | vs Penn State Nittany Lions | W 63-54 |
| December 7, 1959 | vs Pittsburgh Panthers | W 91-79 |
| December 12, 1959 | vs Detroit Mercy | L 63-84 |
| December 15, 1959 | vs DePaul Blue Demons | L 65-87 |
| December 18, 1959 | vs UCLA Bruins | W 75-74 |
| December 22, 1959 | vs Notre Dame Fighting Irish | L 79-82 |
| December 23, 1959 | vs Butler Bulldogs | L 69-73 |
| December 29, 1959 | vs Montana State | W 70-48 |
| January 2, 1960 | vs Indiana Hoosiers | W 79-76 |
| January 9, 1960 | vs Wisconsin Badgers | W 99-69 |
| January 11, 1960 | vs Illinois Fighting Illini | L 75-81 |
| January 16, 1960 | vs Iowa Hawkeyes | L 54-63 |
| January 23, 1960 | vs Ohio State Buckeyes | L 71-85 |
| January 30, 1960 | vs Michigan Wolverines | W 83-63 |
| February 6, 1960 | vs Michigan State Spartans | W 68-65 |
| February 8, 1960 | vs Michigan Wolverines | W 79-65 |
| February 13, 1960 | vs Illinois Fighting Illini (10) | L 89-93 |
| February 15, 1960 | vs Minnesota Golden Gophers (8) | L 69-71 |
| February 20, 1960 | vs Northwestern Wildcats | W 75-70 |
| February 22, 1960 | vs Iowa Hawkeyes | L 68-78 |
| February 27, 1960 | vs Northwestern Wildcats | L 66-68 |
| March 5, 1960 | vs Wisconsin Badgers | L 80-89 |
