| December 4, 1965 | vs Kent State | L 67-79 |
| December 10, 1965 | vs Miami (OH) | L 60-65 |
| December 11, 1965 | vs George Washington | W 85-59 |
| December 22, 1965 | vs Cornell | L 72-81 |
| December 27, 1965 | vs Pennsylvania | L 65-75 |
| December 29, 1965 | vs Columbia | L 59-65 |
| January 4, 1966 | vs Georgia Tech Yellow Jackets | L 77-89 |
| January 8, 1966 | vs Virginia Tech Hokies | L 74-100 |
| January 15, 1966 | vs Bucknell | L 57-66 |
| January 22, 1966 | vs Penn State Nittany Lions | L 62-66 |
| January 25, 1966 | vs West Virginia Mountaineers | L 79-90 |
| January 29, 1966 | vs St. John's (NY) | L 51-74 |
| February 5, 1966 | vs Fordham | L 60-66 |
| February 12, 1966 | vs Temple | L 64-71 |
| February 14, 1966 | vs West Virginia Mountaineers | L 63-103 |
| February 17, 1966 | vs Syracuse Orange | L 73-83 |
| February 26, 1966 | vs Penn State Nittany Lions | L 57-89 |
