| November 13, 2010 | vs Houston Baptist | W 86-73 |
| November 17, 2010 | vs Texas A&M-Corpus Christi | W 68-58 |
| November 21, 2010 | vs Nicholls State | W 76-56 |
| November 25, 2010 | vs DePaul Blue Demons | W 60-56 |
| November 26, 2010 | vs Virginia Tech Hokies | L 51-56 |
| November 28, 2010 | vs Murray State Racers | W 66-49 |
| December 1, 2010 | vs Central Arkansas | W 69-57 |
| December 4, 2010 | vs La Salle | W 92-87 |
| December 8, 2010 | vs Tulsa | W 71-54 |
| December 11, 2010 | vs Missouri State | W 84-70 |
| December 18, 2010 | vs Alabama Crimson Tide | W 68-60 |
| December 21, 2010 | vs Stanford Cardinal | W 79-68 |
| December 31, 2010 | vs Gonzaga Bulldogs | L 52-73 |
| January 3, 2011 | vs Texas-San Antonio | W 79-63 |
| January 8, 2011 | vs Kansas State Wildcats (17) | W 76-62 |
| January 12, 2011 | vs Texas A&M Aggies | L 48-71 |
| January 15, 2011 | vs Colorado Buffaloes | L 71-75 |
| January 19, 2011 | vs Iowa State Cyclones | W 96-87 |
| January 22, 2011 | vs Baylor Bears | L 57-76 |
| January 26, 2011 | vs Texas Longhorns | L 46-61 |
| January 29, 2011 | vs Texas Tech Red Raiders | L 74-75 |
| February 2, 2011 | vs Missouri Tigers | W 76-70 |
| February 5, 2011 | vs Oklahoma Sooners | W 81-75 |
| February 12, 2011 | vs Nebraska Cornhuskers | L 54-65 |
| February 16, 2011 | vs Texas Longhorns | L 55-73 |
| February 19, 2011 | vs Texas A&M Aggies | L 66-67 |
| February 21, 2011 | vs Kansas Jayhawks | L 65-92 |
| February 26, 2011 | vs Texas Tech Red Raiders | W 70-68 |
| March 1, 2011 | vs Baylor Bears | W 71-60 |
| March 5, 2011 | vs Oklahoma Sooners | L 61-64 |
| March 9, 2011 | vs Nebraska Cornhuskers | W 53-52 |
| March 10, 2011 | vs Kansas Jayhawks | L 62-63 |
| March 15, 2011 | vs Harvard | W 71-54 |
| March 21, 2011 | vs Washington State Cougars | L 64-74 |
