| December 1, 1965 | vs Missouri Tigers | W 76-74 |
| December 3, 1965 | vs UCLA Bruins | L 66-92 |
| December 6, 1965 | vs North Carolina Tar Heels | L 72-82 |
| December 8, 1965 | vs Butler Bulldogs | W 75-74 |
| December 18, 1965 | vs Saint Louis | L 58-83 |
| December 20, 1965 | vs Iowa State Cyclones | W 87-70 |
| December 23, 1965 | vs Kansas Jayhawks | L 68-81 |
| December 28, 1965 | vs Wake Forest Demon Deacons | W 88-81 |
| December 31, 1965 | vs West Texas A&M | W 78-53 |
| January 8, 1966 | vs Michigan Wolverines | L 78-83 |
| January 15, 1966 | vs Michigan State Spartans | L 64-80 |
| January 22, 1966 | vs Northwestern Wildcats | W 79-73 |
| January 24, 1966 | vs Iowa Hawkeyes | L 89-98 |
| January 29, 1966 | vs Hardin-Simmons | W 72-64 |
| January 31, 1966 | vs Wisconsin Badgers | W 87-81 |
| February 5, 1966 | vs Illinois Fighting Illini | L 77-78 |
| February 12, 1966 | vs Purdue Boilermakers | W 68-54 |
| February 14, 1966 | vs Indiana Hoosiers | L 61-81 |
| February 19, 1966 | vs Iowa Hawkeyes | L 80-86 |
| February 21, 1966 | vs Minnesota Golden Gophers | W 102-98 |
| February 26, 1966 | vs Northwestern Wildcats | L 77-78 |
| February 28, 1966 | vs Michigan State Spartans | L 79-98 |
| March 5, 1966 | vs Minnesota Golden Gophers | W 94-89 |
| March 7, 1966 | vs Purdue Boilermakers | L 86-92 |
