| December 4, 1965 | vs Wisconsin Badgers | L 79-97 |
| December 11, 1965 | vs Michigan State Spartans | L 69-93 |
| December 15, 1965 | vs Bowling Green State | W 85-77 |
| December 18, 1965 | vs Boston College Eagles | L 89-93 |
| December 21, 1965 | vs Indiana Hoosiers | L 58-80 |
| December 29, 1965 | vs Kentucky Wildcats | L 69-103 |
| December 31, 1965 | vs Duke Blue Devils | L 73-95 |
| January 4, 1966 | vs Purdue Boilermakers | L 92-109 |
| January 8, 1966 | vs Air Force | L 57-68 |
| January 10, 1966 | vs Creighton Bluejays | L 59-72 |
| January 13, 1966 | vs Detroit Mercy | L 84-97 |
| January 15, 1966 | vs DePaul Blue Demons | L 71-97 |
| January 19, 1966 | vs Loyola Marymount | L 86-96 |
| January 28, 1966 | vs Illinois Fighting Illini | L 92-120 |
| January 31, 1966 | vs Butler Bulldogs | L 67-90 |
| February 5, 1966 | vs Georgia Tech Yellow Jackets | L 61-75 |
| February 9, 1966 | vs Butler Bulldogs | W 84-61 |
| February 12, 1966 | vs Detroit Mercy | W 76-67 |
| February 15, 1966 | vs St. John's (NY) | L 59-77 |
| February 17, 1966 | vs New York University | L 78-102 |
| February 19, 1966 | vs Bradley | L 44-55 |
| February 23, 1966 | vs DePaul Blue Demons | L 71-79 |
| February 28, 1966 | vs Western Michigan | L 76-82 |
| March 2, 1966 | vs Creighton Bluejays | L 68-72 |
