| November 18, 2000 | vs Little Rock | L 43-53 |
| November 22, 2000 | vs Maryland-Eastern Shore | W 56-33 |
| November 25, 2000 | vs Vermont | W 64-42 |
| November 28, 2000 | vs Clemson Tigers | L 44-57 |
| December 2, 2000 | vs Mississippi Valley State | W 83-62 |
| December 10, 2000 | vs La Salle | L 44-62 |
| December 13, 2000 | vs Saint Peter's | W 83-56 |
| December 16, 2000 | vs Pepperdine | L 53-55 |
| December 20, 2000 | vs Kent State | L 58-67 |
| December 21, 2000 | vs Iona Gaels | W 69-67 |
| December 22, 2000 | vs Evansville | W 68-52 |
| December 27, 2000 | vs USC Trojans | W 63-61 |
| January 3, 2001 | vs Ohio State Buckeyes | L 56-73 |
| January 6, 2001 | vs Purdue Boilermakers | L 61-69 |
| January 10, 2001 | vs Michigan State Spartans | L 53-84 |
| January 13, 2001 | vs Penn State Nittany Lions | L 66-73 |
| January 17, 2001 | vs Illinois Fighting Illini | L 49-63 |
| January 20, 2001 | vs Purdue Boilermakers | L 59-78 |
| January 24, 2001 | vs Michigan State Spartans | L 58-74 |
| January 27, 2001 | vs Michigan Wolverines | L 65-72 |
| January 31, 2001 | vs Buffalo Bulls | W 79-63 |
| February 3, 2001 | vs Illinois Fighting Illini | L 59-84 |
| February 6, 2001 | vs Minnesota Golden Gophers | L 59-66 |
| February 10, 2001 | vs Iowa Hawkeyes (19) | W 69-61 |
| February 14, 2001 | vs Indiana Hoosiers | L 54-78 |
| February 18, 2001 | vs Wisconsin Badgers | L 37-59 |
| February 21, 2001 | vs Penn State Nittany Lions | W 62-61 |
| February 24, 2001 | vs Ohio State Buckeyes | L 57-69 |
| February 28, 2001 | vs Michigan Wolverines | W 75-70 |
| March 8, 2001 | vs Iowa Hawkeyes | L 55-72 |
