| December 4, 1965 | vs Ohio | W 62-60 |
| December 6, 1965 | vs Colorado Buffaloes | L 55-70 |
| December 11, 1965 | vs Kentucky Wildcats | L 75-86 |
| December 18, 1965 | vs Tulane Green Wave | W 61-48 |
| December 20, 1965 | vs Missouri Tigers | W 67-60 |
| December 21, 1965 | vs Texas Longhorns | W 73-71 |
| December 23, 1965 | vs Vanderbilt Commodores | L 58-59 |
| December 27, 1965 | vs USC Trojans | L 63-75 |
| December 28, 1965 | vs Syracuse Orange | L 75-105 |
| December 30, 1965 | vs LSU Tigers | W 98-86 |
| January 8, 1966 | vs Purdue Boilermakers | W 111-97 |
| January 10, 1966 | vs Iowa Hawkeyes | L 58-70 |
| January 15, 1966 | vs Michigan Wolverines | L 86-93 |
| January 22, 1966 | vs Ohio State Buckeyes | L 73-79 |
| January 29, 1966 | vs Michigan State Spartans | L 68-77 |
| February 1, 1966 | vs Minnesota Golden Gophers | L 76-86 |
| February 7, 1966 | vs Illinois Fighting Illini | W 80-77 |
| February 12, 1966 | vs Iowa Hawkeyes (9) | W 81-73 |
| February 19, 1966 | vs Indiana Hoosiers | W 83-82 |
| February 21, 1966 | vs Wisconsin Badgers | W 76-65 |
| February 26, 1966 | vs Ohio State Buckeyes | W 78-77 |
| February 28, 1966 | vs Wisconsin Badgers | L 62-90 |
| March 5, 1966 | vs Michigan Wolverines | L 92-105 |
| March 7, 1966 | vs Illinois Fighting Illini | W 84-76 |
