| November 22, 2000 | vs Rhode Island Rams | W 70-60 |
| November 24, 2000 | vs Valparaiso | W 77-61 |
| November 25, 2000 | vs Syracuse Orange | L 62-84 |
| December 2, 2000 | vs Texas-Rio Grande Valley | W 78-57 |
| December 6, 2000 | vs DePaul Blue Demons | W 99-84 |
| December 9, 2000 | vs Saint Louis | W 77-73 |
| December 16, 2000 | vs Iowa Hawkeyes | L 94-99 |
| December 18, 2000 | vs Indiana Hoosiers | W 68-63 |
| December 21, 2000 | vs Illinois Fighting Illini | L 81-86 |
| December 30, 2000 | vs Stetson | W 89-64 |
| January 2, 2001 | vs Coastal Carolina | W 75-61 |
| January 6, 2001 | vs Nebraska Cornhuskers | W 68-66 |
| January 10, 2001 | vs Colorado Buffaloes | W 82-76 |
| January 13, 2001 | vs Iowa State Cyclones | W 112-109 |
| January 16, 2001 | vs Kansas State Wildcats | L 59-80 |
| January 20, 2001 | vs Virginia Cavaliers | L 72-85 |
| January 24, 2001 | vs Nebraska Cornhuskers | L 79-85 |
| January 27, 2001 | vs Texas Tech Red Raiders | W 66-64 |
| January 29, 2001 | vs Kansas Jayhawks | W 75-66 |
| February 5, 2001 | vs Oklahoma State Cowboys | L 66-69 |
| February 7, 2001 | vs Kansas State Wildcats | W 70-66 |
| February 11, 2001 | vs Iowa State Cyclones | L 64-72 |
| February 14, 2001 | vs Colorado Buffaloes | W 80-69 |
| February 17, 2001 | vs Texas A&M Aggies | W 97-90 |
| February 19, 2001 | vs Oklahoma Sooners | L 61-63 |
| February 24, 2001 | vs Baylor Bears | W 69-59 |
| February 26, 2001 | vs Texas Longhorns | L 61-76 |
| March 4, 2001 | vs Kansas Jayhawks | L 59-75 |
| March 8, 2001 | vs Texas A&M Aggies | W 77-62 |
| March 9, 2001 | vs Oklahoma Sooners | L 65-67 |
| March 15, 2001 | vs Georgia Bulldogs | W 70-68 |
| March 17, 2001 | vs Duke Blue Devils | L 81-94 |
