| December 1, 1965 | vs Ohio State Buckeyes | L 74-76 |
| December 4, 1965 | vs Arkansas Razorbacks | L 62-75 |
| December 11, 1965 | vs Saint Louis | L 55-81 |
| December 13, 1965 | vs Rice | W 96-87 |
| December 15, 1965 | vs Loyola (IL) | L 85-108 |
| December 20, 1965 | vs Northwestern Wildcats | L 60-67 |
| December 21, 1965 | vs Memphis Tigers | L 72-85 |
| December 27, 1965 | vs Nebraska Cornhuskers | L 67-69 |
| December 29, 1965 | vs Oklahoma State Cowboys | W 65-63 |
| December 30, 1965 | vs Kansas State Wildcats | L 70-90 |
| January 3, 1966 | vs Kansas State Wildcats | L 59-78 |
| January 8, 1966 | vs Nebraska Cornhuskers | L 60-82 |
| January 10, 1966 | vs Iowa State Cyclones | L 70-85 |
| January 29, 1966 | vs Oklahoma Sooners | L 70-88 |
| January 31, 1966 | vs Oklahoma State Cowboys | L 50-67 |
| February 5, 1966 | vs Kansas Jayhawks | L 54-77 |
| February 7, 1966 | vs Colorado Buffaloes | L 60-65 |
| February 12, 1966 | vs Oklahoma Sooners | L 89-103 |
| February 15, 1966 | vs Kansas Jayhawks | L 54-98 |
| February 19, 1966 | vs Nebraska Cornhuskers | L 53-71 |
| February 21, 1966 | vs Kansas State Wildcats (8) | L 61-85 |
| February 26, 1966 | vs Colorado Buffaloes | W 64-63 |
| February 28, 1966 | vs Oklahoma State Cowboys | L 51-68 |
| March 3, 1966 | vs Iowa State Cyclones | L 73-79 |
