| December 4, 1965 | vs Iowa State Cyclones | W 80-69 |
| December 7, 1965 | vs Drake | W 81-67 |
| December 18, 1965 | vs Creighton Bluejays | W 89-77 |
| December 20, 1965 | vs Detroit Mercy | W 92-88 |
| December 23, 1965 | vs Utah State Aggies | L 72-97 |
| December 27, 1965 | vs Cornell | W 84-82 |
| December 29, 1965 | vs Saint Joseph's | L 66-91 |
| December 30, 1965 | vs La Salle | W 92-87 |
| December 31, 1965 | vs Loyola (IL) | L 69-82 |
| January 8, 1966 | vs Michigan State Spartans | L 65-85 |
| January 15, 1966 | vs Indiana Hoosiers | W 91-82 |
| January 22, 1966 | vs Michigan Wolverines | L 85-97 |
| January 29, 1966 | vs Purdue Boilermakers | W 91-75 |
| February 1, 1966 | vs Northwestern Wildcats | W 86-76 |
| February 5, 1966 | vs Purdue Boilermakers | W 66-61 |
| February 12, 1966 | vs Michigan State Spartans | W 81-71 |
| February 15, 1966 | vs Iowa Hawkeyes | L 87-96 |
| February 19, 1966 | vs Illinois Fighting Illini | L 89-100 |
| February 21, 1966 | vs Ohio State Buckeyes | L 98-102 |
| February 26, 1966 | vs Illinois Fighting Illini | W 94-92 |
| February 28, 1966 | vs Indiana Hoosiers | W 96-90 |
| March 5, 1966 | vs Ohio State Buckeyes | L 89-94 |
| March 7, 1966 | vs Wisconsin Badgers | L 74-87 |
