| December 1, 1965 | vs Penn State Nittany Lions | L 61-65 |
| December 4, 1965 | vs Wake Forest Demon Deacons | W 87-66 |
| December 7, 1965 | vs North Carolina State Wolfpack | W 59-48 |
| December 10, 1965 | vs Kansas Jayhawks | L 62-71 |
| December 11, 1965 | vs Kansas State Wildcats | W 63-57 |
| December 15, 1965 | vs Georgetown Hoyas | W 77-59 |
| December 21, 1965 | vs West Virginia Mountaineers | L 74-76 |
| December 29, 1965 | vs Houston Cougars | W 69-68 |
| December 30, 1965 | vs Dayton Flyers | W 77-75 |
| January 3, 1966 | vs North Carolina Tar Heels | L 52-67 |
| January 5, 1966 | vs Virginia Cavaliers | L 62-65 |
| January 13, 1966 | vs Duke Blue Devils | L 61-76 |
| January 15, 1966 | vs North Carolina State Wolfpack | L 58-60 |
| January 27, 1966 | vs George Washington | W 107-81 |
| January 29, 1966 | vs Clemson Tigers | L 66-71 |
| January 31, 1966 | vs South Carolina Gamecocks | W 78-63 |
| February 5, 1966 | vs North Carolina Tar Heels | W 76-66 |
| February 7, 1966 | vs Wake Forest Demon Deacons | W 86-78 |
| February 9, 1966 | vs Navy | W 74-69 |
| February 12, 1966 | vs West Virginia Mountaineers | W 107-92 |
| February 16, 1966 | vs Virginia Cavaliers | W 71-64 |
| February 19, 1966 | vs Duke Blue Devils | L 69-74 |
| February 25, 1966 | vs South Carolina Gamecocks | W 56-42 |
| February 26, 1966 | vs Clemson Tigers | L 69-81 |
| March 3, 1966 | vs North Carolina Tar Heels | L 70-77 |
