| December 4, 1965 | vs DePaul Blue Demons | L 69-82 |
| December 9, 1965 | vs Davidson Wildcats | L 65-73 |
| December 11, 1965 | vs Louisville Cardinals | L 61-70 |
| December 17, 1965 | vs West Virginia Mountaineers | W 100-87 |
| December 18, 1965 | vs Washington Huskies | W 75-74 |
| December 22, 1965 | vs Wichita State Shockers | W 95-76 |
| December 28, 1965 | vs Yale | W 74-68 |
| January 3, 1966 | vs Wisconsin Badgers | L 72-73 |
| January 5, 1966 | vs Loyola (IL) | L 65-87 |
| January 8, 1966 | vs Xavier Musketeers | W 103-64 |
| January 11, 1966 | vs Toledo | L 71-77 |
| January 29, 1966 | vs Detroit Mercy | W 81-74 |
| February 5, 1966 | vs Loyola (IL) | L 84-85 |
| February 9, 1966 | vs DePaul Blue Demons | L 70-76 |
| February 12, 1966 | vs Air Force | L 79-83 |
| February 16, 1966 | vs Xavier Musketeers | L 78-82 |
| February 26, 1966 | vs St. John's (NY) | L 68-70 |
| February 28, 1966 | vs Niagara | W 71-67 |
| March 3, 1966 | vs Detroit Mercy | W 87-78 |
