| November 12, 2010 | vs Longwood | W 113-75 |
| November 15, 2010 | vs Valparaiso | W 79-44 |
| November 19, 2010 | vs North Texas | W 93-60 |
| November 23, 2010 | vs Texas A&M-Corpus Christi | W 82-41 |
| November 26, 2010 | vs Ohio | W 98-41 |
| November 27, 2010 | vs Arizona Wildcats | W 87-79 |
| December 2, 2010 | vs UCLA Bruins | W 77-76 |
| December 7, 2010 | vs Memphis Tigers (13) | W 81-68 |
| December 11, 2010 | vs Colorado State Rams | W 76-55 |
| December 18, 2010 | vs USC Trojans | W 70-68 |
| December 22, 2010 | vs California Golden Bears | W 78-63 |
| December 29, 2010 | vs Texas-Arlington | W 82-57 |
| January 2, 2011 | vs Miami (OH) | W 83-56 |
| January 5, 2011 | vs Missouri-Kansas City | W 99-52 |
| January 9, 2011 | vs Michigan Wolverines | W 67-60 |
| January 12, 2011 | vs Iowa State Cyclones | W 84-79 |
| January 15, 2011 | vs Nebraska Cornhuskers | W 63-60 |
| January 17, 2011 | vs Baylor Bears | W 85-65 |
| January 22, 2011 | vs Texas Longhorns | L 63-74 |
| January 25, 2011 | vs Colorado Buffaloes | W 82-78 |
| January 29, 2011 | vs Kansas State Wildcats | W 90-66 |
| February 1, 2011 | vs Texas Tech Red Raiders | W 88-66 |
| February 5, 2011 | vs Nebraska Cornhuskers | W 86-66 |
| February 7, 2011 | vs Missouri Tigers | W 103-86 |
| February 12, 2011 | vs Iowa State Cyclones | W 89-66 |
| February 14, 2011 | vs Kansas State Wildcats | L 68-84 |
| February 19, 2011 | vs Colorado Buffaloes | W 89-63 |
| February 21, 2011 | vs Oklahoma State Cowboys | W 92-65 |
| February 26, 2011 | vs Oklahoma Sooners | W 82-70 |
| March 2, 2011 | vs Texas A&M Aggies | W 64-51 |
| March 5, 2011 | vs Missouri Tigers | W 70-66 |
| March 10, 2011 | vs Oklahoma State Cowboys | W 63-62 |
| March 11, 2011 | vs Colorado Buffaloes | W 90-83 |
| March 12, 2011 | vs Texas Longhorns | W 85-73 |
| March 18, 2011 | vs Boston University | W 72-53 |
| March 20, 2011 | vs Illinois Fighting Illini | W 73-59 |
| March 25, 2011 | vs Richmond | W 77-57 |
| March 27, 2011 | vs VCU Rams | L 61-71 |
