| December 1, 1965 | vs Arkansas Razorbacks | W 81-52 |
| December 4, 1965 | vs Texas Tech Red Raiders | W 74-70 |
| December 7, 1965 | vs New Mexico State | W 102-51 |
| December 10, 1965 | vs Maryland Terrapins | W 71-62 |
| December 11, 1965 | vs St. John's (NY) | W 61-55 |
| December 17, 1965 | vs UCLA Bruins | L 71-78 |
| December 18, 1965 | vs USC Trojans | L 69-81 |
| December 23, 1965 | vs Ohio State Buckeyes | W 81-68 |
| December 28, 1965 | vs Kansas State Wildcats | W 69-63 |
| December 29, 1965 | vs Iowa State Cyclones | W 73-66 |
| December 30, 1965 | vs Nebraska Cornhuskers | W 71-61 |
| January 3, 1966 | vs Colorado Buffaloes | W 69-55 |
| January 8, 1966 | vs Iowa State Cyclones | W 82-65 |
| January 10, 1966 | vs Oklahoma Sooners | W 89-68 |
| January 15, 1966 | vs Iowa State Cyclones | W 49-47 |
| January 18, 1966 | vs Nebraska Cornhuskers | L 75-83 |
| January 22, 1966 | vs Kansas State Wildcats | W 69-61 |
| February 5, 1966 | vs Missouri Tigers | W 77-54 |
| February 12, 1966 | vs Oklahoma State Cowboys | W 59-38 |
| February 15, 1966 | vs Missouri Tigers | W 98-54 |
| February 19, 1966 | vs Oklahoma State Cowboys | W 80-47 |
| February 21, 1966 | vs Oklahoma Sooners | W 86-69 |
| February 26, 1966 | vs Nebraska Cornhuskers | W 110-73 |
| March 5, 1966 | vs Kansas State Wildcats | W 68-55 |
| March 7, 1966 | vs Colorado Buffaloes | W 85-65 |
| March 11, 1966 | vs Southern Methodist | W 76-70 |
| March 12, 1966 | vs Texas-El Paso | L 80-81 |
