| November 12, 2010 | vs James Madison | W 75-61 |
| November 16, 2010 | vs Virginia Tech Hokies (22) | W 73-57 |
| November 18, 2010 | vs Presbyterian | W 76-67 |
| November 22, 2010 | vs Gonzaga Bulldogs (22) | W 81-64 |
| November 23, 2010 | vs Duke Blue Devils (1) | L 68-82 |
| November 26, 2010 | vs Texas Southern | W 84-60 |
| December 3, 2010 | vs Washington State Cougars | W 63-58 |
| December 6, 2010 | vs Alcorn State | W 89-55 |
| December 11, 2010 | vs Loyola (IL) | W 68-60 |
| December 18, 2010 | vs Florida Gators | L 44-57 |
| December 21, 2010 | vs Nevada-Las Vegas | L 59-63 |
| December 23, 2010 | vs Missouri-Kansas City | W 80-64 |
| December 31, 2010 | vs North Florida | W 100-76 |
| January 3, 2011 | vs Savannah State | W 92-61 |
| January 8, 2011 | vs Oklahoma State Cowboys | L 62-76 |
| January 12, 2011 | vs Colorado Buffaloes | L 66-74 |
| January 15, 2011 | vs Texas Tech Red Raiders | W 94-60 |
| January 17, 2011 | vs Missouri Tigers | L 59-75 |
| January 22, 2011 | vs Texas A&M Aggies | L 56-64 |
| January 24, 2011 | vs Baylor Bears | W 69-61 |
| January 29, 2011 | vs Kansas Jayhawks | L 66-90 |
| February 2, 2011 | vs Nebraska Cornhuskers | W 69-53 |
| February 5, 2011 | vs Iowa State Cyclones | W 86-85 |
| February 12, 2011 | vs Colorado Buffaloes | L 56-58 |
| February 14, 2011 | vs Kansas Jayhawks | W 84-68 |
| February 19, 2011 | vs Oklahoma Sooners | W 77-62 |
| February 23, 2011 | vs Nebraska Cornhuskers | W 61-57 |
| February 26, 2011 | vs Missouri Tigers | W 80-70 |
| February 28, 2011 | vs Texas Longhorns | W 75-70 |
| March 5, 2011 | vs Iowa State Cyclones | W 67-55 |
| March 10, 2011 | vs Colorado Buffaloes | L 75-87 |
| March 17, 2011 | vs Utah State | W 73-68 |
| March 19, 2011 | vs Wisconsin Badgers | L 65-70 |
