| December 1, 1965 | vs Creighton Bluejays | L 75-83 |
| December 4, 1965 | vs Tulsa | L 63-70 |
| December 10, 1965 | vs St. John's (NY) | L 65-72 |
| December 11, 1965 | vs Maryland Terrapins | L 57-63 |
| December 13, 1965 | vs Indiana Hoosiers | W 103-76 |
| December 16, 1965 | vs Texas Tech Red Raiders | W 74-68 |
| December 18, 1965 | vs Stanford Cardinal | W 73-65 |
| December 28, 1965 | vs Kansas Jayhawks | L 63-69 |
| December 29, 1965 | vs Colorado Buffaloes | W 87-67 |
| December 30, 1965 | vs Missouri Tigers | W 90-70 |
| January 3, 1966 | vs Missouri Tigers | W 78-59 |
| January 8, 1966 | vs Oklahoma State Cowboys | W 67-47 |
| January 15, 1966 | vs Nebraska Cornhuskers | L 71-82 |
| January 22, 1966 | vs Kansas Jayhawks | L 61-69 |
| January 29, 1966 | vs Loyola (IL) | L 70-76 |
| February 5, 1966 | vs Oklahoma Sooners | W 84-73 |
| February 7, 1966 | vs Oklahoma State Cowboys | W 50-44 |
| February 12, 1966 | vs Colorado Buffaloes | W 65-55 |
| February 14, 1966 | vs Iowa State Cyclones | W 80-69 |
| February 19, 1966 | vs Colorado Buffaloes | W 68-52 |
| February 21, 1966 | vs Missouri Tigers | W 85-61 |
| February 26, 1966 | vs Oklahoma Sooners | L 77-80 |
| March 1, 1966 | vs Nebraska Cornhuskers | L 69-79 |
| March 5, 1966 | vs Kansas Jayhawks | L 55-68 |
| March 7, 1966 | vs Iowa State Cyclones | W 75-73 |
