| December 2, 1965 | vs Pepperdine | W 111-50 |
| December 8, 1965 | vs Creighton Bluejays | W 103-77 |
| December 11, 1965 | vs Drake | W 66-60 |
| December 15, 1965 | vs Washington Huskies | W 99-70 |
| December 18, 1965 | vs Drake | W 69-51 |
| December 29, 1965 | vs Arkansas Razorbacks | W 77-75 |
| December 30, 1965 | vs Texas-El Paso | L 68-86 |
| January 8, 1966 | vs Wisconsin Badgers | L 68-69 |
| January 10, 1966 | vs Northwestern Wildcats | W 70-58 |
| January 17, 1966 | vs Indiana Hoosiers | L 61-73 |
| January 22, 1966 | vs Michigan State Spartans | W 90-76 |
| January 24, 1966 | vs Ohio State Buckeyes | W 98-89 |
| February 5, 1966 | vs Detroit Mercy | W 107-73 |
| February 7, 1966 | vs Purdue Boilermakers | L 58-66 |
| February 12, 1966 | vs Northwestern Wildcats | L 73-81 |
| February 15, 1966 | vs Minnesota Golden Gophers | W 96-87 |
| February 19, 1966 | vs Ohio State Buckeyes | W 86-80 |
| February 21, 1966 | vs Michigan Wolverines | W 91-82 |
| February 26, 1966 | vs Wisconsin Badgers | W 80-70 |
| February 28, 1966 | vs Michigan Wolverines | L 88-103 |
| March 5, 1966 | vs Illinois Fighting Illini | L 90-106 |
| March 7, 1966 | vs Indiana Hoosiers | W 82-77 |
