| December 4, 1965 | vs Oklahoma Sooners | L 82-83 |
| December 6, 1965 | vs Detroit Mercy | L 75-78 |
| December 13, 1965 | vs Kansas State Wildcats | L 76-103 |
| December 17, 1965 | vs California Golden Bears | W 71-64 |
| December 18, 1965 | vs Kentucky Wildcats | L 56-91 |
| December 21, 1965 | vs Notre Dame Fighting Irish | W 80-58 |
| December 31, 1965 | vs Bradley | W 104-87 |
| January 3, 1966 | vs Loyola (IL) | L 68-91 |
| January 8, 1966 | vs Illinois Fighting Illini | L 84-98 |
| January 10, 1966 | vs Michigan Wolverines | L 68-88 |
| January 15, 1966 | vs Minnesota Golden Gophers | L 82-91 |
| January 17, 1966 | vs Iowa Hawkeyes | W 73-61 |
| February 1, 1966 | vs DePaul Blue Demons | L 79-100 |
| February 5, 1966 | vs Michigan Wolverines | L 76-93 |
| February 7, 1966 | vs Wisconsin Badgers | L 78-79 |
| February 12, 1966 | vs Illinois Fighting Illini | W 81-77 |
| February 14, 1966 | vs Ohio State Buckeyes | W 81-61 |
| February 19, 1966 | vs Northwestern Wildcats | L 82-83 |
| February 21, 1966 | vs Purdue Boilermakers | L 68-77 |
| February 26, 1966 | vs Michigan State Spartans | L 63-69 |
| February 28, 1966 | vs Minnesota Golden Gophers | L 90-96 |
| March 5, 1966 | vs Michigan State Spartans | W 86-76 |
| March 7, 1966 | vs Iowa Hawkeyes | L 77-82 |
