| December 7, 1959 | vs Missouri Tigers | L 76-79 |
| December 12, 1959 | vs Ohio | W 80-68 |
| December 14, 1959 | vs Kansas State Wildcats | W 67-58 |
| December 19, 1959 | vs Detroit Mercy | W 89-85 |
| December 22, 1959 | vs Butler Bulldogs | W 91-85 |
| December 23, 1959 | vs Notre Dame Fighting Irish | W 71-60 |
| December 28, 1959 | vs Maryland Terrapins | W 72-63 |
| December 29, 1959 | vs Louisville Cardinals | W 90-71 |
| January 2, 1960 | vs Purdue Boilermakers | L 76-79 |
| January 4, 1960 | vs Northwestern Wildcats | L 57-61 |
| January 9, 1960 | vs Ohio State Buckeyes | L 95-96 |
| January 11, 1960 | vs Michigan Wolverines | W 77-72 |
| January 30, 1960 | vs DePaul Blue Demons | W 82-78 |
| February 1, 1960 | vs Northwestern Wildcats | W 76-58 |
| February 6, 1960 | vs Wisconsin Badgers | W 97-85 |
| February 8, 1960 | vs Iowa Hawkeyes | W 87-74 |
| February 13, 1960 | vs Wisconsin Badgers | W 91-71 |
| February 15, 1960 | vs Michigan Wolverines | W 86-69 |
| February 20, 1960 | vs Iowa Hawkeyes (15) | W 79-64 |
| February 22, 1960 | vs Illinois Fighting Illini | W 92-78 |
| February 27, 1960 | vs Minnesota Golden Gophers | W 78-74 |
| February 29, 1960 | vs Ohio State Buckeyes | W 99-83 |
| March 5, 1960 | vs Michigan State Spartans | W 86-80 |
