| November 25, 2020 | vs North Carolina A&T | W 122-60 |
| November 26, 2020 | vs Wright State | |
| November 26, 2020 | vs Chicago State | W 97-38 |
| November 27, 2020 | vs Ohio | W 77-75 |
| December 2, 2020 | vs Baylor Bears | L 69-82 |
| December 5, 2020 | vs Tennessee-Martin | |
| December 8, 2020 | vs Duke Blue Devils | W 83-68 |
| December 12, 2020 | vs Missouri Tigers | L 78-81 |
| December 15, 2020 | vs Minnesota Golden Gophers | W 92-65 |
| December 20, 2020 | vs Rutgers Scarlet Knights | L 88-91 |
| December 23, 2020 | vs Penn State Nittany Lions | W 98-81 |
| December 26, 2020 | vs Indiana Hoosiers | W 69-60 |
| January 2, 2021 | vs Purdue Boilermakers | W 66-58 |
| January 7, 2021 | vs Northwestern Wildcats | W 81-56 |
| January 10, 2021 | vs Maryland Terrapins | L 63-66 |
| January 13, 2021 | vs Nebraska Cornhuskers | |
| January 16, 2021 | vs Ohio State Buckeyes | L 81-87 |
| January 19, 2021 | vs Penn State Nittany Lions | W 79-65 |
| January 20, 2021 | vs Penn State Nittany Lions | |
| January 23, 2021 | vs Michigan State Spartans | |
| January 29, 2021 | vs Iowa Hawkeyes | W 80-75 |
| February 2, 2021 | vs Indiana Hoosiers | W 75-71 |
| February 6, 2021 | vs Wisconsin Badgers | W 75-60 |
| February 11, 2021 | vs Michigan Wolverines | |
| February 12, 2021 | vs Nebraska Cornhuskers | W 77-72 |
| February 16, 2021 | vs Northwestern Wildcats | W 73-66 |
| February 20, 2021 | vs Minnesota Golden Gophers | W 94-63 |
| February 23, 2021 | vs Michigan State Spartans | L 72-81 |
| February 24, 2021 | vs Nebraska Cornhuskers | |
| February 25, 2021 | vs Nebraska Cornhuskers | |
| February 27, 2021 | vs Wisconsin Badgers | |
| March 2, 2021 | vs Nebraska Cornhuskers | |
| March 2, 2021 | vs Michigan Wolverines | |
| March 6, 2021 | vs Ohio State Buckeyes | |
