| November 8, 2018 | vs Evansville | W 99-60 |
| November 13, 2018 | vs Georgetown Hoyas | L 80-88 |
| November 19, 2018 | vs Gonzaga Bulldogs (3) | L 78-84 |
| November 20, 2018 | vs Iowa State Cyclones | L 68-84 |
| November 21, 2018 | vs Xavier Musketeers | L 74-83 |
| November 25, 2018 | vs Mississippi Valley State | W 86-67 |
| November 27, 2018 | vs Notre Dame Fighting Irish | L 74-76 |
| December 2, 2018 | vs Nebraska Cornhuskers | L 60-75 |
| December 5, 2018 | vs Ohio State Buckeyes (19) | L 67-77 |
| December 8, 2018 | vs UNLV Rebels | W 77-74 |
| December 15, 2018 | vs East Tennessee State | W 73-55 |
| December 22, 2018 | vs Missouri Tigers | L 63-79 |
| December 29, 2018 | vs Florida Atlantic | L 71-73 |
| January 3, 2019 | vs Indiana Hoosiers (21) | L 65-73 |
| January 6, 2019 | vs Northwestern Wildcats | L 66-68 |
| January 10, 2019 | vs Michigan Wolverines (2) | L 69-79 |
| January 16, 2019 | vs Minnesota Golden Gophers | W 95-68 |
| January 20, 2019 | vs Iowa Hawkeyes (23) | L 71-95 |
| January 23, 2019 | vs Wisconsin Badgers | L 60-72 |
| January 26, 2019 | vs Maryland Terrapins (13) | W 78-67 |
| January 30, 2019 | vs Minnesota Golden Gophers | L 75-86 |
| February 2, 2019 | vs Nebraska Cornhuskers | W 71-64 |
| February 5, 2019 | vs Michigan State Spartans (9) | W 79-74 |
| February 9, 2019 | vs Rutgers Scarlet Knights | W 99-94 |
| February 14, 2019 | vs Ohio State Buckeyes | W 63-56 |
| February 18, 2019 | vs Wisconsin Badgers (22) | L 58-64 |
| February 23, 2019 | vs Penn State Nittany Lions | L 76-83 |
| February 27, 2019 | vs Purdue Boilermakers (14) | L 56-73 |
| March 3, 2019 | vs Northwestern Wildcats | W 81-76 |
| March 7, 2019 | vs Indiana Hoosiers | L 74-92 |
| March 10, 2019 | vs Penn State Nittany Lions | L 56-72 |
| March 13, 2019 | vs Northwestern Wildcats | W 74-69 |
| March 14, 2019 | vs Iowa Hawkeyes | L 62-83 |
