| December 1, 1965 | vs Butler Bulldogs | W 88-74 |
| December 2, 1965 | vs BYU Cougars | L 98-109 |
| December 4, 1965 | vs UCLA Bruins | L 79-97 |
| December 8, 1965 | vs Kentucky Wildcats | L 68-86 |
| December 11, 1965 | vs West Virginia Mountaineers | W 96-86 |
| December 14, 1965 | vs Wisconsin Badgers | W 90-70 |
| December 18, 1965 | vs Princeton | L 81-84 |
| December 27, 1965 | vs Georgetown Hoyas | W 96-94 |
| December 28, 1965 | vs Providence Friars | L 79-81 |
| December 30, 1965 | vs Army | L 69-78 |
| January 8, 1966 | vs Indiana Hoosiers | W 98-84 |
| January 11, 1966 | vs Wisconsin Badgers | W 80-64 |
| January 15, 1966 | vs Purdue Boilermakers | L 87-93 |
| January 28, 1966 | vs Notre Dame Fighting Irish | W 120-92 |
| February 1, 1966 | vs Michigan Wolverines | W 99-93 |
| February 5, 1966 | vs Ohio State Buckeyes | W 78-77 |
| February 7, 1966 | vs Northwestern Wildcats | L 77-80 |
| February 12, 1966 | vs Indiana Hoosiers | L 77-81 |
| February 19, 1966 | vs Minnesota Golden Gophers | W 100-89 |
| February 22, 1966 | vs Michigan State Spartans | L 66-68 |
| February 26, 1966 | vs Minnesota Golden Gophers | L 92-94 |
| February 28, 1966 | vs Purdue Boilermakers | W 98-81 |
| March 5, 1966 | vs Iowa Hawkeyes | W 106-90 |
| March 7, 1966 | vs Northwestern Wildcats | L 76-84 |
