| November 9, 2021 | vs Miami (OH) | L 69-72 |
| November 12, 2021 | vs Stetson | W 77-52 |
| November 15, 2021 | vs Lamar | W 75-66 |
| November 19, 2021 | vs Georgia Bulldogs | W 88-78 |
| November 22, 2021 | vs Charleston Southern | W 85-70 |
| November 26, 2021 | vs Georgia Southern | W 61-59 |
| December 1, 2021 | vs Wisconsin Badgers | L 66-70 |
| December 5, 2021 | vs North Carolina Tar Heels | L 62-79 |
| December 11, 2021 | vs LSU Tigers | L 53-69 |
| December 18, 2021 | vs USC Trojans | L 53-67 |
| December 21, 2021 | vs Georgia State | W 72-62 |
| December 23, 2021 | vs Alabama A&M | |
| December 29, 2021 | vs Syracuse Orange | |
| January 1, 2022 | vs Louisville Cardinals | |
| January 2, 2022 | vs Louisville Cardinals | L 64-67 |
| January 4, 2022 | vs Duke Blue Devils | L 57-69 |
| January 8, 2022 | vs Notre Dame Fighting Irish | L 68-72 |
| January 12, 2022 | vs Boston College Eagles | W 81-76 |
| January 15, 2022 | vs North Carolina Tar Heels | L 65-88 |
| January 19, 2022 | vs Wake Forest Demon Deacons | L 64-80 |
| January 23, 2022 | vs Clayton State | W 103-53 |
| January 26, 2022 | vs Florida State Seminoles | W 75-61 |
| January 29, 2022 | vs Miami (FL) Hurricanes | L 62-73 |
| February 2, 2022 | vs Virginia Tech Hokies | L 66-81 |
| February 5, 2022 | vs Clemson Tigers | W 69-64 |
| February 9, 2022 | vs Miami (FL) Hurricanes | L 70-79 |
| February 12, 2022 | vs Virginia Cavaliers | L 53-63 |
| February 15, 2022 | vs North Carolina State Wolfpack | L 61-76 |
| February 19, 2022 | vs Pittsburgh Panthers | W 68-62 |
| February 21, 2022 | vs Syracuse Orange | L 73-74 |
| February 23, 2022 | vs Virginia Tech Hokies | L 58-62 |
| February 26, 2022 | vs Notre Dame Fighting Irish | L 56-90 |
| March 2, 2022 | vs Clemson Tigers | L 65-68 |
| March 5, 2022 | vs Boston College Eagles | W 82-78 |
| March 8, 2022 | vs Louisville Cardinals | L 74-84 |
