| December 1, 1965 | vs Illinois Fighting Illini | L 74-88 |
| December 3, 1965 | vs USC Trojans | W 77-75 |
| December 8, 1965 | vs Ohio State Buckeyes | L 74-75 |
| December 9, 1965 | vs Michigan State Spartans | L 56-75 |
| December 11, 1965 | vs Purdue Boilermakers | L 77-84 |
| December 16, 1965 | vs Bradley | L 70-73 |
| December 22, 1965 | vs Michigan Wolverines | W 79-64 |
| December 23, 1965 | vs Oklahoma Sooners | W 65-63 |
| December 29, 1965 | vs Toledo | W 89-79 |
| January 1, 1966 | vs Yale | W 75-67 |
| January 31, 1966 | vs Notre Dame Fighting Irish | W 90-67 |
| February 9, 1966 | vs Notre Dame Fighting Irish | L 61-84 |
