| November 12, 2010 | vs St. Francis (NY) | W 79-49 |
| November 18, 2010 | vs Yale | L 67-75 |
| November 22, 2010 | vs Holy Cross | W 69-54 |
| November 25, 2010 | vs Texas A&M Aggies | W 67-65 |
| November 26, 2010 | vs Wisconsin Badgers | L 55-65 |
| November 28, 2010 | vs California Golden Bears | W 68-46 |
| December 1, 2010 | vs Indiana Hoosiers | W 88-76 |
| December 4, 2010 | vs UMass Minutemen | W 76-71 |
| December 8, 2010 | vs Providence Friars | W 88-86 |
| December 12, 2010 | vs Maryland Terrapins | W 79-75 |
| December 19, 2010 | vs Bryant | W 93-77 |
| December 22, 2010 | vs Bucknell | W 84-80 |
| December 29, 2010 | vs Rhode Island Rams | L 65-67 |
| January 1, 2011 | vs South Carolina Gamecocks | W 85-70 |
| January 5, 2011 | vs Harvard | L 69-78 |
| January 8, 2011 | vs Georgia Tech Yellow Jackets | W 86-75 |
| January 11, 2011 | vs North Carolina State Wolfpack | W 75-66 |
| January 15, 2011 | vs Miami (FL) Hurricanes | L 71-72 |
| January 19, 2011 | vs Virginia Cavaliers | W 70-67 |
| January 22, 2011 | vs Florida State Seminoles | L 51-67 |
| January 27, 2011 | vs Duke Blue Devils | L 68-84 |
| February 1, 2011 | vs North Carolina Tar Heels (23) | L 74-106 |
| February 5, 2011 | vs Virginia Tech Hokies | W 58-56 |
| February 8, 2011 | vs Clemson Tigers | L 69-77 |
| February 12, 2011 | vs Maryland Terrapins | W 76-72 |
| February 19, 2011 | vs North Carolina Tar Heels | L 46-48 |
| February 23, 2011 | vs Miami (FL) Hurricanes | L 64-73 |
| February 26, 2011 | vs Virginia Cavaliers | W 63-44 |
| March 1, 2011 | vs Virginia Tech Hokies | W 76-61 |
| March 6, 2011 | vs Wake Forest Demon Deacons | W 84-68 |
| March 10, 2011 | vs Wake Forest Demon Deacons | W 81-67 |
| March 11, 2011 | vs Clemson Tigers | L 47-70 |
| March 15, 2011 | vs McNeese State | W 82-64 |
| March 19, 2011 | vs Northwestern Wildcats | L 67-85 |
